藥物交互作用
Cisapride + Ribociclib
嚴重程度: 禁忌併用
Cisapride and Ribociclib: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ribociclib is a moderate CYP3A4 inhibitor and also prolongs the QT interval in a dose-dependent manner. Combined with cisapride, which is a CYP3A4 substrate with a known risk of torsades de pointes, this could produce serious arrhythmia.
用白話說明這項交互作用的意義
Cisapride and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Ribociclib belongs to Oncology.
為什麼會發生
Ribociclib inhibits CYP3A4, which may increase cisapride exposure, and both drugs prolong the QT interval additively.
處置方式
Avoid the combination and choose a non-QT-prolonging prokinetic or antiemetic. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cisapride 的其他交互作用
Ribociclib 的其他交互作用
常見問題
Can I take Cisapride with Ribociclib?
MediHelp rates the interaction as contraindicated. Cisapride and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ribociclib is a moderate CYP3A4 inhibitor and also prolongs the QT interval in a dose-dependent manner. Combined with cisapride, which is a CYP3A4 substrate with a known risk of torsades de pointes, this could produce serious arrhythmia.
How serious is the interaction between Cisapride and Ribociclib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging prokinetic or antiemetic. If it cannot be avoided, specialist supervision with ECG and electrolyte monitoring is required.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
