藥物交互作用
Dofetilide + Ribociclib
嚴重程度: 禁忌併用
Dofetilide and Ribociclib: contraindicated interaction.
最後更新
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摘要
Both drugs prolong the QT interval, and the combination raises the risk of torsades de pointes. Dofetilide has a narrow therapeutic margin for proarrhythmia.
用白話說明這項交互作用的意義
Dofetilide and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Ribociclib belongs to Oncology.
為什麼會發生
Additive prolongation of cardiac repolarization through QT-prolonging effects.
處置方式
Do not combine; use an alternative antiarrhythmic or an alternative anticancer strategy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ribociclib 的其他交互作用
Dofetilide 的其他交互作用
常見問題
Can I take Dofetilide with Ribociclib?
MediHelp rates the interaction as contraindicated. Dofetilide and Ribociclib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and the combination raises the risk of torsades de pointes. Dofetilide has a narrow therapeutic margin for proarrhythmia.
How serious is the interaction between Dofetilide and Ribociclib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiarrhythmic or an alternative anticancer strategy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dronedarone. The full list is on the Ribociclib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
