藥物交互作用
Cisapride + Tipranavir
嚴重程度: 禁忌併用
Cisapride and Tipranavir: contraindicated interaction.
最後更新
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摘要
Tipranavir given with ritonavir inhibits CYP3A4, which clears cisapride. Increased cisapride concentrations may cause QT prolongation and life-threatening arrhythmias.
用白話說明這項交互作用的意義
Cisapride and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.
為什麼會發生
CYP3A4 inhibition by ritonavir-boosted tipranavir reduces cisapride metabolism.
處置方式
Do not coadminister; use an alternative prokinetic.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cisapride 的其他交互作用
Tipranavir 的其他交互作用
常見問題
Can I take Cisapride with Tipranavir?
MediHelp rates the interaction as contraindicated. Cisapride and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir given with ritonavir inhibits CYP3A4, which clears cisapride. Increased cisapride concentrations may cause QT prolongation and life-threatening arrhythmias.
How serious is the interaction between Cisapride and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative prokinetic.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
