藥品參考
Tipranavir
Tipranavir is a medicine in the class anti virals. It is used for hiv.
- 藥物類別: Anti Virals
- 用途: hiv
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Anti Virals
- ATC 代碼
- J05AE09
- 已知交互作用
- 276 (禁忌併用: 26 · 嚴重: 96 · 中度: 132 · 輕微: 22)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Tipranavir is a non-peptidic HIV-1 protease inhibitor that blocks maturation of viral particles and so inhibits viral replication.
成人常用劑量（仿單摘要）
HIV-1 infection (highly pre-treated, adults and adolescents 12-18 years with BSA ≥ 1.3 m2 or weight ≥ 36 kg): 500 mg tipranavir with 200 mg ritonavir, oral, twice daily; ritonavir doses below 200 mg twice daily should not be used
懷孕與哺乳
- 懷孕
- Unknown Limited data (no birth defects in 13 1st-trimester registry exposures); reproductive toxicity in animals. EU label: use only if benefit justifies the risk. It weakens estrogen pills; use another contraceptive. Better-studied HIV drugs are preferred in pregnancy.
- 哺乳
- Unknown No human milk data; present in rat milk. EU label: women with HIV should not breastfeed (transmission). US guidance supports breastfeeding with sustained viral suppression after counselling; otherwise use formula or donor milk (LactMed).
已通報的副作用
- Rash
禁忌症
- Hypersensitivity to the active substance or excipients
- Moderate or severe (Child-Pugh B or C) hepatic impairment
- Rifampicin combination with Aptivus/low dose ritonavir
哪些人需要特別留意
- Must be given with low dose ritonavir; otherwise tipranavir levels may be insufficient
- Hepatotoxicity: clinical hepatitis and hepatic decompensation, including fatalities; monitor liver tests; discontinue if ASAT/ALAT rise above 10X ULN
- Should not be used in treatment-naive patients
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (276)
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
- Dronedarone + Tipranavir Contraindicated
- Eletriptan + Tipranavir Contraindicated
- Eplerenone + Tipranavir Contraindicated
- Ergotamine + Tipranavir Contraindicated
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Tipranavir 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
相關快速閱讀
常見問題
What is Tipranavir used for?
Tipranavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Tipranavir?
Rash.
Can Tipranavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited data (no birth defects in 13 1st-trimester registry exposures); reproductive toxicity in animals. EU label: use only if benefit justifies the risk. It weakens estrogen pills; use another contraceptive. Better-studied HIV drugs are preferred in pregnancy. Breastfeeding: Unknown. No human milk data; present in rat milk. EU label: women with HIV should not breastfeed (transmission). US guidance supports breastfeeding with sustained viral suppression after counselling; otherwise use formula or donor milk (LactMed).
What does Tipranavir interact with?
MediHelp lists 276 known interactions for Tipranavir. Contraindicated: 26 · Major: 96 · Moderate: 132 · Minor: 22. The most serious include Alfuzosin, Amiodarone, Atorvastatin.
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