藥物交互作用
Citalopram + Methylene blue
嚴重程度: 禁忌併用
Citalopram and Methylene blue: contraindicated interaction.
最後更新
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摘要
Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
用白話說明這項交互作用的意義
Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Reversible MAO-A inhibition by methylene blue added to SSRI-mediated serotonin reuptake blockade.
處置方式
Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Citalopram 的其他交互作用
常見問題
Can I take Citalopram with Methylene blue?
MediHelp rates the interaction as contraindicated. Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
How serious is the interaction between Citalopram and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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