藥物交互作用
Citalopram + Phenelzine
嚴重程度: 禁忌併用
Citalopram and Phenelzine: contraindicated interaction.
最後更新
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摘要
Citalopram raises synaptic serotonin by blocking reuptake, and phenelzine (an irreversible non-selective MAO inhibitor) prevents its breakdown. Serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability can develop, sometimes fatally.
用白話說明這項交互作用的意義
Citalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Citalopram belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
為什麼會發生
Serotonin reuptake inhibition combined with MAO inhibition causes excess serotonergic activity
處置方式
Contraindicated. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least 2 weeks between stopping an irreversible MAOI and starting citalopram, and about a week the other way round.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Citalopram 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Citalopram with Phenelzine?
MediHelp rates the interaction as contraindicated. Citalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Citalopram raises synaptic serotonin by blocking reuptake, and phenelzine (an irreversible non-selective MAO inhibitor) prevents its breakdown. Serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability can develop, sometimes fatally.
How serious is the interaction between Citalopram and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least 2 weeks between stopping an irreversible MAOI and starting citalopram, and about a week the other way round.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
