藥物交互作用
Clarithromycin + Dihydroergotamine intranasal
嚴重程度: 禁忌併用
Clarithromycin and Dihydroergotamine intranasal: contraindicated interaction.
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摘要
Even with intranasal use, systemic exposure to dihydroergotamine is sufficient that strong CYP3A4 inhibition by clarithromycin can cause ergotism, with severe vasospasm and ischemia of extremities and the CNS.
用白話說明這項交互作用的意義
Clarithromycin and Dihydroergotamine intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Clarithromycin inhibits CYP3A4 and decreases clearance of dihydroergotamine.
處置方式
Do not coadminister; use an alternative antibiotic such as azithromycin and advise patients to report cold, numb or painful extremities immediately.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
常見問題
Can I take Clarithromycin with Dihydroergotamine intranasal?
MediHelp rates the interaction as contraindicated. Clarithromycin and Dihydroergotamine intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Even with intranasal use, systemic exposure to dihydroergotamine is sufficient that strong CYP3A4 inhibition by clarithromycin can cause ergotism, with severe vasospasm and ischemia of extremities and the CNS.
How serious is the interaction between Clarithromycin and Dihydroergotamine intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic such as azithromycin and advise patients to report cold, numb or painful extremities immediately.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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