藥物交互作用
Astemizole + Clarithromycin
嚴重程度: 禁忌併用
Astemizole and Clarithromycin: contraindicated interaction.
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Clarithromycin raises astemizole concentrations and, together with the intrinsic QT effect of both drugs, may cause torsades de pointes and sudden death. The combination is contraindicated. Astemizole has been withdrawn in many markets, so the interaction is mainly of historical relevance.
用白話說明這項交互作用的意義
Astemizole and Clarithromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Clarithromycin inhibits CYP3A4-mediated metabolism of astemizole and also prolongs QT through IKr blockade, giving pharmacokinetic and pharmacodynamic synergy.
處置方式
Do not combine. Use a non-sedating antihistamine without QT liability, such as fexofenadine, loratadine or cetirizine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
Clarithromycin 的其他交互作用
常見問題
Can I take Astemizole with Clarithromycin?
MediHelp rates the interaction as contraindicated. Astemizole and Clarithromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin raises astemizole concentrations and, together with the intrinsic QT effect of both drugs, may cause torsades de pointes and sudden death. The combination is contraindicated. Astemizole has been withdrawn in many markets, so the interaction is mainly of historical relevance.
How serious is the interaction between Astemizole and Clarithromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-sedating antihistamine without QT liability, such as fexofenadine, loratadine or cetirizine.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Avanafil, Cisapride, Colchicine. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
