藥物交互作用
Clarithromycin + Erdafitinib
嚴重程度: 嚴重
Clarithromycin and Erdafitinib: major interaction.
最後更新
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摘要
Strong CYP3A4 inhibitors increase erdafitinib exposure, raising the risk of adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.
用白話說明這項交互作用的意義
Clarithromycin and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Erdafitinib belongs to Oncology.
為什麼會發生
Clarithromycin inhibits CYP3A4, which contributes to erdafitinib metabolism along with CYP2C9.
處置方式
Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, monitor closely for erdafitinib toxicity and reduce the dose as needed, then reassess after clarithromycin is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Erdafitinib 的其他交互作用
常見問題
Can I take Clarithromycin with Erdafitinib?
MediHelp rates the interaction as major. Clarithromycin and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase erdafitinib exposure, raising the risk of adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.
How serious is the interaction between Clarithromycin and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, monitor closely for erdafitinib toxicity and reduce the dose as needed, then reassess after clarithromycin is stopped.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
