藥物交互作用
Clozapine + Insulin degludec-liraglutide
嚴重程度: 嚴重
Clozapine and Insulin degludec-liraglutide: major interaction.
最後更新
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摘要
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can substantially undermine glycemic control with insulin degludec-liraglutide.
用白話說明這項交互作用的意義
Clozapine and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
為什麼會發生
Clozapine induces insulin resistance and may impair pancreatic insulin secretion and promote weight gain, opposing antidiabetic therapy.
處置方式
Monitor blood glucose frequently, particularly when clozapine is started or titrated, and increase antidiabetic therapy as needed. Reassess the regimen if hyperglycemia persists.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin degludec-liraglutide 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Clozapine and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can substantially undermine glycemic control with insulin degludec-liraglutide.
How serious is the interaction between Clozapine and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently, particularly when clozapine is started or titrated, and increase antidiabetic therapy as needed. Reassess the regimen if hyperglycemia persists.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Diazoxide. The full list is on the Insulin degludec-liraglutide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
