藥物交互作用
Chlorpropamide + Insulin degludec-liraglutide
嚴重程度: 嚴重
Chlorpropamide and Insulin degludec-liraglutide: major interaction.
最後更新
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摘要
Chlorpropamide, a long-acting sulfonylurea, combined with insulin and liraglutide substantially raises the risk of hypoglycemia, which can be severe and prolonged, especially in older adults or those with renal impairment.
用白話說明這項交互作用的意義
Chlorpropamide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
為什麼會發生
Additive glucose lowering from sulfonylurea-driven insulin secretion, exogenous insulin and glucose-dependent GLP-1 receptor stimulation.
處置方式
Reduce the sulfonylurea dose, or preferably replace chlorpropamide with a safer agent, and monitor blood glucose closely. Educate patients on recognizing and treating hypoglycemia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin degludec-liraglutide 的其他交互作用
Chlorpropamide 的其他交互作用
常見問題
Can I take Chlorpropamide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Chlorpropamide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpropamide, a long-acting sulfonylurea, combined with insulin and liraglutide substantially raises the risk of hypoglycemia, which can be severe and prolonged, especially in older adults or those with renal impairment.
How serious is the interaction between Chlorpropamide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the sulfonylurea dose, or preferably replace chlorpropamide with a safer agent, and monitor blood glucose closely. Educate patients on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Clozapine, Diazoxide. The full list is on the Insulin degludec-liraglutide page.
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