藥物交互作用
Conivaptan + Erythromycin
嚴重程度: 禁忌併用
Conivaptan and Erythromycin: contraindicated interaction.
最後更新
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摘要
Erythromycin is a CYP3A4 inhibitor and conivaptan is a CYP3A4 substrate and inhibitor, so concentrations of conivaptan may rise, causing excessive vasopressin antagonism with overly rapid sodium correction. Conivaptan labeling contraindicates potent CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Conivaptan and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Erythromycin inhibits CYP3A4 metabolism of conivaptan.
處置方式
Avoid the combination and use a non-CYP3A4-inhibiting antibiotic. If exposure occurs, monitor serum sodium frequently to prevent overly rapid correction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Erythromycin 的其他交互作用
常見問題
Can I take Conivaptan with Erythromycin?
MediHelp rates the interaction as contraindicated. Conivaptan and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin is a CYP3A4 inhibitor and conivaptan is a CYP3A4 substrate and inhibitor, so concentrations of conivaptan may rise, causing excessive vasopressin antagonism with overly rapid sodium correction. Conivaptan labeling contraindicates potent CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antibiotic. If exposure occurs, monitor serum sodium frequently to prevent overly rapid correction.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Domperidone. The full list is on the Erythromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
