藥物交互作用
Dihydroergotamine intranasal + Erythromycin
嚴重程度: 禁忌併用
Dihydroergotamine intranasal and Erythromycin: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Erythromycin inhibits CYP3A4 metabolism of dihydroergotamine.
處置方式
Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Erythromycin 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Erythromycin?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
How serious is the interaction between Dihydroergotamine intranasal and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine, Domperidone. The full list is on the Erythromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
