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Droperidol + Erythromycin

嚴重程度: 禁忌併用

Droperidol and Erythromycin: contraindicated interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Both agents prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Giving them together substantially increases the risk of life-threatening ventricular arrhythmia.

用白話說明這項交互作用的意義

Droperidol and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

證據等級: High

為什麼會發生

Additive QT prolongation from hERG potassium channel blockade, with erythromycin possibly raising droperidol levels via CYP3A4 inhibition.

處置方式

Avoid the combination and use a non-QT-prolonging antibiotic or antiemetic. If droperidol is essential, do not co-administer erythromycin.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

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建立帳號並開始 Pro+ 試用，即可解鎖 Droperidol 與 Erythromycin 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Droperidol with Erythromycin?

MediHelp rates the interaction as contraindicated. Droperidol and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Giving them together substantially increases the risk of life-threatening ventricular arrhythmia.

How serious is the interaction between Droperidol and Erythromycin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic or antiemetic. If droperidol is essential, do not co-administer erythromycin.

What other medicines interact with Erythromycin?

MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.

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