藥品參考
Exagamglogene autotemcel
Exagamglogene autotemcel is a medicine in the class miscellaneous. It is used for sickle cell disease.
- 藥物類別: Miscellaneous
- 用途: sickle cell disease
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- B06AX05
- 已知交互作用
- 6 (嚴重: 4 · 中度: 2)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Edited autologous CD34+ cells engraft in bone marrow and differentiate into erythroid cells with reduced BCL11A expression, increasing gamma-globin and HbF production. In SCD, HbF reduces intracellular HbS and red cell sickling; in TDT it improves globin imbalance and reduces transfusion dependence.
成人常用劑量（仿單摘要）
SCD with recurrent VOCs or transfusion-dependent beta-thalassemia: minimum dose 3 × 10 6 CD34+ cells/kg, single one-time intravenous infusion; administer all vials, 48 hours to 7 days after the last myeloablative conditioning dose
懷孕與哺乳
- 懷孕
- Unsafe No clinical or animal data. Must not be administered during pregnancy because of risks of myeloablative conditioning.
- 哺乳
- Unsafe No data on milk presence or effects. Breastfeeding should be discontinued during conditioning because of myeloablative risks.
已通報的副作用
- Mucositis
- Febrile neutropenia
- Decreased appetite
- Neutropenia
- Thrombocytopenia
- Leukopenia
哪些人需要特別留意
- Risk of neutrophil engraftment failure; monitor ANC and give rescue CD34+ cells if it occurs. G-CSF not recommended for 21 days after infusion.
- Delayed platelet engraftment with increased bleeding risk; monitor platelets frequently until recovery.
- Hypersensitivity including anaphylaxis can occur due to DMSO or dextran 40 in the cryopreservation solution.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (6)
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Exagamglogene autotemcel 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同類別的其他藥品
常見問題
What is Exagamglogene autotemcel used for?
Exagamglogene autotemcel is a medicine in the class miscellaneous. It is used for Sickle cell disease, Thalassemia.
What side effects have been reported with Exagamglogene autotemcel?
Mucositis, Febrile neutropenia, Decreased appetite, Neutropenia, Thrombocytopenia, Leukopenia.
Can Exagamglogene autotemcel be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical or animal data. Must not be administered during pregnancy because of risks of myeloablative conditioning. Breastfeeding: Unsafe. No data on milk presence or effects. Breastfeeding should be discontinued during conditioning because of myeloablative risks.
What does Exagamglogene autotemcel interact with?
MediHelp lists 6 known interactions for Exagamglogene autotemcel. Major: 4 · Moderate: 2. The most serious include Deferasirox, Deferiprone, Deferoxamine.
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