藥物交互作用
Cyclobenzaprine + Phenelzine
嚴重程度: 禁忌併用
Cyclobenzaprine and Phenelzine: contraindicated interaction.
最後更新
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摘要
Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
用白話說明這項交互作用的意義
Cyclobenzaprine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
為什麼會發生
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
處置方式
Do not combine; allow at least 14 days after stopping the phenelzine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the phenelzine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cyclobenzaprine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Cyclobenzaprine with Phenelzine?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the phenelzine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the phenelzine.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Safinamide. The full list is on the Cyclobenzaprine page.
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