藥物交互作用
Cyclobenzaprine + Linezolid
嚴重程度: 禁忌併用
Cyclobenzaprine and Linezolid: contraindicated interaction.
最後更新
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摘要
Linezolid is a reversible non-selective MAO inhibitor, and cyclobenzaprine has serotonergic activity, so combined use can precipitate serotonin syndrome. Cyclobenzaprine labeling also contraindicates use with MAO inhibitors because of the risk of severe reactions.
用白話說明這項交互作用的意義
Cyclobenzaprine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Linezolid belongs to Anti Bacterial.
為什麼會發生
MAO inhibition by linezolid combined with serotonin reuptake inhibition by cyclobenzaprine increases synaptic serotonin.
處置方式
Avoid concurrent use and choose an alternative antibiotic or muscle relaxant. If linezolid is essential, stop cyclobenzaprine and monitor for serotonin syndrome.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cyclobenzaprine 的其他交互作用
Linezolid 的其他交互作用
常見問題
Can I take Cyclobenzaprine with Linezolid?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible non-selective MAO inhibitor, and cyclobenzaprine has serotonergic activity, so combined use can precipitate serotonin syndrome. Cyclobenzaprine labeling also contraindicates use with MAO inhibitors because of the risk of severe reactions.
How serious is the interaction between Cyclobenzaprine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antibiotic or muscle relaxant. If linezolid is essential, stop cyclobenzaprine and monitor for serotonin syndrome.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Phenelzine, Safinamide. The full list is on the Cyclobenzaprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
