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Cyclosporin + Glycerol phenylbutyrate

嚴重程度: 中度

Cyclosporin and Glycerol phenylbutyrate: moderate interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.

用白話說明這項交互作用的意義

Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cyclosporin belongs to Miscellaneous; Glycerol phenylbutyrate belongs to Miscellaneous.

證據等級: Low

為什麼會發生

Weak induction of CYP3A4 increases cyclosporine metabolism.

處置方式

Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Cyclosporin 與 Glycerol phenylbutyrate 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Cyclosporin with Glycerol phenylbutyrate?

MediHelp rates the interaction as moderate. Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.

How serious is the interaction between Cyclosporin and Glycerol phenylbutyrate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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