藥物交互作用
Dexamethasone-tobramycin + Glycerol phenylbutyrate
嚴重程度: 中度
Dexamethasone-tobramycin and Glycerol phenylbutyrate: moderate interaction.
最後更新
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摘要
Corticosteroids promote protein catabolism and can raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. The concern is mainly with systemic dexamethasone.
用白話說明這項交互作用的意義
Dexamethasone-tobramycin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Glycerol phenylbutyrate belongs to Miscellaneous.
為什麼會發生
Corticosteroid-induced protein breakdown increases nitrogen load and ammonia.
處置方式
Monitor plasma ammonia closely if systemic corticosteroids are used and adjust the phenylbutyrate dose as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dexamethasone-tobramycin 的其他交互作用
Glycerol phenylbutyrate 的其他交互作用
常見問題
Can I take Dexamethasone-tobramycin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. The concern is mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-tobramycin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely if systemic corticosteroids are used and adjust the phenylbutyrate dose as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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