藥物交互作用
Fludrocortisone + Glycerol phenylbutyrate
嚴重程度: 中度
Fludrocortisone and Glycerol phenylbutyrate: moderate interaction.
最後更新
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摘要
Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
用白話說明這項交互作用的意義
Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Glycerol phenylbutyrate belongs to Miscellaneous.
為什麼會發生
Corticosteroid-driven protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen scavenging effect.
處置方式
Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Fludrocortisone 的其他交互作用
Glycerol phenylbutyrate 的其他交互作用
常見問題
Can I take Fludrocortisone with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Fludrocortisone and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein breakdown and can raise plasma ammonia, which counteracts the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders. This may risk hyperammonemia.
How serious is the interaction between Fludrocortisone and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when fludrocortisone is started or adjusted, and adjust the glycerol phenylbutyrate dose or protein intake as needed.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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