藥物交互作用

Cyclosporin + Pitavastatin

嚴重程度: 禁忌併用

Cyclosporin and Pitavastatin: contraindicated interaction.

最後更新 29 十月 2026 來源: US FDA label

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摘要

Cyclosporine inhibits OATP1B1 and BCRP, which clears pitavastatin, and can raise pitavastatin exposure several-fold. This greatly increases the risk of myopathy and rhabdomyolysis.

用白話說明這項交互作用的意義

Cyclosporin and Pitavastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclosporin belongs to Miscellaneous; Pitavastatin belongs to Cardiovascular.

證據等級: High

為什麼會發生

OATP1B1/BCRP inhibition raises statin exposure

處置方式

Contraindicated by labelling; use a different statin and monitor for muscle symptoms if exposure occurs.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Cyclosporin 與 Pitavastatin 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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參考資料

Pitavastatin - FDA drug label (DailyMed) - section 7 Drug Interactions (names the partner; "Cyclosporine significantly increases pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis.") — DailyMed (FDA label)

Adenovirus types 4 and 7 live + Cyclosporin 禁忌併用
Aliskiren + Cyclosporin 禁忌併用
Bcg vaccine live + Cyclosporin 禁忌併用
Bosentan + Cyclosporin 禁忌併用
Cidofovir + Cyclosporin 禁忌併用
Cyclosporin + Dengue vaccine 禁忌併用

Erythromycin base + Pitavastatin 嚴重
Erythromycin ethylsuccinate + Pitavastatin 嚴重
Erythromycin lactobionate + Pitavastatin 嚴重
Erythromycin stearate + Pitavastatin 嚴重
Erythromycin + Pitavastatin 嚴重
Gemfibrozil + Pitavastatin 嚴重

常見問題

Can I take Cyclosporin with Pitavastatin?

MediHelp rates the interaction as contraindicated. Cyclosporin and Pitavastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits OATP1B1 and BCRP, which clears pitavastatin, and can raise pitavastatin exposure several-fold. This greatly increases the risk of myopathy and rhabdomyolysis.

How serious is the interaction between Cyclosporin and Pitavastatin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated by labelling; use a different statin and monitor for muscle symptoms if exposure occurs.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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摘要