藥物交互作用
Gemfibrozil + Pitavastatin
嚴重程度: 嚴重
Gemfibrozil and Pitavastatin: major interaction.
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
摘要
Gemfibrozil inhibits OATP1B1 and glucuronidation, which can raise pitavastatin exposure, and fibrates themselves can cause myopathy. The risk of myopathy and rhabdomyolysis rises accordingly.
用白話說明這項交互作用的意義
Gemfibrozil and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.
為什麼會發生
OATP1B1 inhibition raising statin exposure plus additive myotoxicity
處置方式
Avoid the combination; if a fibrate is needed, use a different class or fenofibrate, and monitor for muscle symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Pitavastatin 的其他交互作用
Gemfibrozil 的其他交互作用
常見問題
Can I take Gemfibrozil with Pitavastatin?
MediHelp rates the interaction as major. Gemfibrozil and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation, which can raise pitavastatin exposure, and fibrates themselves can cause myopathy. The risk of myopathy and rhabdomyolysis rises accordingly.
How serious is the interaction between Gemfibrozil and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a fibrate is needed, use a different class or fenofibrate, and monitor for muscle symptoms.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
