藥物交互作用
Dabrafenib + Desogestrel-ethinyl estradiol
嚴重程度: 嚴重
Dabrafenib and Desogestrel-ethinyl estradiol: major interaction.
最後更新
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摘要
Dabrafenib is an inducer of CYP3A4 and can lower exposure to hormonal contraceptives. Contraceptive efficacy may be reduced, leading to a risk of pregnancy during treatment with a teratogenic agent.
用白話說明這項交互作用的意義
Dabrafenib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
為什麼會發生
Dabrafenib induces CYP3A4, accelerating metabolism of ethinyl estradiol and etonogestrel.
處置方式
Use an effective non-hormonal contraceptive method during dabrafenib therapy and for a period after discontinuation, as specified in labeling.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Desogestrel-ethinyl estradiol 的其他交互作用
Dabrafenib 的其他交互作用
常見問題
Can I take Dabrafenib with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Dabrafenib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is an inducer of CYP3A4 and can lower exposure to hormonal contraceptives. Contraceptive efficacy may be reduced, leading to a risk of pregnancy during treatment with a teratogenic agent.
How serious is the interaction between Dabrafenib and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during dabrafenib therapy and for a period after discontinuation, as specified in labeling.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
