藥物交互作用
Dabrafenib + Sofosbuvir-velpatasvir
嚴重程度: 嚴重
Dabrafenib and Sofosbuvir-velpatasvir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dabrafenib induces CYP3A4, CYP2C8 and probably P-gp, which can lower velpatasvir and sofosbuvir concentrations. This may reduce antiviral efficacy and risk treatment failure or resistance.
用白話說明這項交互作用的意義
Dabrafenib and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Sofosbuvir-velpatasvir belongs to Anti Virals.
為什麼會發生
Dabrafenib induces CYP3A4/CYP2C8/CYP2B6 and P-gp, increasing clearance of velpatasvir and sofosbuvir.
處置方式
Avoid coadministration and use an alternative HCV regimen or defer HCV therapy. If it cannot be avoided, monitor HCV RNA.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Sofosbuvir-velpatasvir 的其他交互作用
Dabrafenib 的其他交互作用
常見問題
Can I take Dabrafenib with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as major. Dabrafenib and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4, CYP2C8 and probably P-gp, which can lower velpatasvir and sofosbuvir concentrations. This may reduce antiviral efficacy and risk treatment failure or resistance.
How serious is the interaction between Dabrafenib and Sofosbuvir-velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative HCV regimen or defer HCV therapy. If it cannot be avoided, monitor HCV RNA.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
