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藥物交互作用

Rifapentine + Sofosbuvir-velpatasvir

嚴重程度: 禁忌併用

Rifapentine and Sofosbuvir-velpatasvir: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Rifapentine is a strong inducer of CYP3A4 and P-gp and is expected to substantially reduce velpatasvir and sofosbuvir levels. This may lead to HCV treatment failure.

用白話說明這項交互作用的意義

Rifapentine and Sofosbuvir-velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Rifapentine belongs to Anti Bacterial; Sofosbuvir-velpatasvir belongs to Anti Virals.

證據等級: Moderate

為什麼會發生

Rifapentine induces P-gp and CYP3A4/2B6/2C8, increasing antiviral clearance.

處置方式

Avoid concurrent use and defer HCV therapy until rifapentine is finished, or choose a different TB regimen.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Rifapentine 與 Sofosbuvir-velpatasvir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Rifapentine with Sofosbuvir-velpatasvir?

MediHelp rates the interaction as contraindicated. Rifapentine and Sofosbuvir-velpatasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is a strong inducer of CYP3A4 and P-gp and is expected to substantially reduce velpatasvir and sofosbuvir levels. This may lead to HCV treatment failure.

How serious is the interaction between Rifapentine and Sofosbuvir-velpatasvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and defer HCV therapy until rifapentine is finished, or choose a different TB regimen.

What other medicines interact with Sofosbuvir-velpatasvir?

MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, St john's wort, Amiodarone. The full list is on the Sofosbuvir-velpatasvir page.

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