藥物交互作用
Amiodarone + Sofosbuvir-velpatasvir
嚴重程度: 嚴重
Amiodarone and Sofosbuvir-velpatasvir: major interaction.
最後更新
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摘要
Co-administration of sofosbuvir-containing regimens with amiodarone has been associated with severe symptomatic bradycardia, including fatal cases and pacemaker insertion. Risk appears higher with beta-blockers, cardiac disease or advanced liver disease.
用白話說明這項交互作用的意義
Amiodarone and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Sofosbuvir-velpatasvir belongs to Anti Virals.
為什麼會發生
The mechanism is not established; an additive effect on cardiac conduction is suspected.
處置方式
Avoid the combination where possible; if unavoidable, monitor the patient with continuous cardiac monitoring in hospital for the first 48 hours, then check heart rate daily or self-monitor for the first 2 weeks.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Sofosbuvir-velpatasvir 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as major. Amiodarone and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Co-administration of sofosbuvir-containing regimens with amiodarone has been associated with severe symptomatic bradycardia, including fatal cases and pacemaker insertion. Risk appears higher with beta-blockers, cardiac disease or advanced liver disease.
How serious is the interaction between Amiodarone and Sofosbuvir-velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, monitor the patient with continuous cardiac monitoring in hospital for the first 48 hours, then check heart rate daily or self-monitor for the first 2 weeks.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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