藥物交互作用
Dapagliflozin-metformin + Niacin
嚴重程度: 中度
Dapagliflozin-metformin and Niacin: moderate interaction.
最後更新
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摘要
Niacin, especially at lipid-lowering doses, can worsen insulin resistance and raise blood glucose. This may reduce the effectiveness of antidiabetic therapy.
用白話說明這項交互作用的意義
Dapagliflozin-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Niacin belongs to Cardiovascular.
為什麼會發生
Pharmacodynamic antagonism through niacin-induced insulin resistance and increased hepatic glucose output.
處置方式
Monitor glucose and HbA1c after starting or increasing niacin and increase antidiabetic therapy if needed. Reassess glucose when niacin is stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dapagliflozin-metformin 的其他交互作用
Niacin 的其他交互作用
常見問題
Can I take Dapagliflozin-metformin with Niacin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin, especially at lipid-lowering doses, can worsen insulin resistance and raise blood glucose. This may reduce the effectiveness of antidiabetic therapy.
How serious is the interaction between Dapagliflozin-metformin and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or increasing niacin and increase antidiabetic therapy if needed. Reassess glucose when niacin is stopped.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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