藥物交互作用
Darunavir + Eletriptan
嚴重程度: 禁忌併用
Darunavir and Eletriptan: contraindicated interaction.
最後更新
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摘要
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Eletriptan belongs to Central Nervous System.
為什麼會發生
Potent inhibition of CYP3A4-mediated eletriptan metabolism, mainly via the ritonavir or cobicistat booster.
處置方式
Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Eletriptan?
MediHelp rates the interaction as contraindicated. Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.
How serious is the interaction between Darunavir and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
