藥物交互作用
Darunavir + Red yeast rice
嚴重程度: 嚴重
Darunavir and Red yeast rice: major interaction.
最後更新
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摘要
Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.
用白話說明這項交互作用的意義
Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Red yeast rice belongs to Gastrointestinal Tract.
為什麼會發生
Boosted darunavir inhibits CYP3A4, reducing monacolin K metabolism.
處置方式
Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Red yeast rice 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Red yeast rice?
MediHelp rates the interaction as major. Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.
How serious is the interaction between Darunavir and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
