藥物交互作用
Darunavir + Regorafenib
嚴重程度: 嚴重
Darunavir and Regorafenib: major interaction.
最後更新
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摘要
Darunavir, especially when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase regorafenib exposure, with unpredictable changes in active metabolites.
用白話說明這項交互作用的意義
Darunavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Regorafenib belongs to Oncology.
為什麼會發生
CYP3A4 inhibition by boosted darunavir reduces regorafenib clearance.
處置方式
Avoid the combination if possible. If coadministration is necessary, monitor liver function and for adverse reactions.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Regorafenib 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Regorafenib?
MediHelp rates the interaction as major. Darunavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, especially when boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase regorafenib exposure, with unpredictable changes in active metabolites.
How serious is the interaction between Darunavir and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If coadministration is necessary, monitor liver function and for adverse reactions.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
