藥品參考

Regorafenib

Regorafenib is a medicine in the class oncology. It is used for colorectal cancer.

藥物類別: Oncology
用途: colorectal cancer

最後更新 29 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別: Oncology
ATC 代碼: L01EX05
常見劑型: 錠劑
常見規格: 40 mg
已知交互作用: 118 (嚴重: 41 · 中度: 60 · 輕微: 17)
商品名: 5
國家與市場: 5

劑型、規格與商品名稱會因國家而異。請核對您手上的產品。

用途

作用方式

Tyrosine kinase inhibitor; shown to inhibit activity of membrane-bound and intracellular kinases involved in normal cellular functions and in pathological processes (eg, oncogenesis, tumor angiogenesis)

成人常用劑量（仿單摘要）

160 mg (four 40-mg tablets) PO qDay for the first 21 days of each 28-day cycle

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕: Unsafe Can cause fetal harm: no human data, but it caused total pregnancy loss and malformations (heart, kidney, skeleton, cleft palate) in rats and rabbits at below human exposure. Avoid; use effective contraception during and for 2 months after treatment (men too).
哺乳: Unsafe No human milk data; it passes into rat milk. Over 99% protein bound, but a metabolite with a half-life of up to 70 hours could build up in the infant. Do not breastfeed during treatment and for 2 weeks after the last dose.

已通報的副作用

Asthenia
Anemia
Lymphopenia
Increased AST
Proteinuria
Hypocalcemia

哪些人需要特別留意

Increased risk of infections reported; most common infections include urinary tract infections, nasopharyngitis, mucocutaneous and systemic fungal infections and pneumoni
May cause severe drug-induced liver injury with fatal outcome

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (118)

Apalutamide + Regorafenib Major
Atazanavir + Regorafenib Major
Carbamazepine + Regorafenib Major
Clarithromycin + Regorafenib Major
Conivaptan + Regorafenib Major
Dabrafenib + Regorafenib Major
Darunavir + Regorafenib Major
Duvelisib + Regorafenib Major
Efavirenz + Regorafenib Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Regorafenib Major

All 118 interactions, with severity and what to do

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可開啟 Regorafenib 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。

Dosing by age, kidney and liver function, and further dose lines
Paediatric dosing
Patient counselling points
Food interactions

建立免費帳號登入

在網頁版免費試用 Pro+ 7 天，無需信用卡。

同類別的其他藥品

常見問題

What is Regorafenib used for?

Regorafenib is a medicine in the class oncology. It is used for Colorectal cancer, Gastrointestinal tumors, Hepatocellular carcinoma.

What side effects have been reported with Regorafenib?

Asthenia, Anemia, Lymphopenia, Increased AST, Proteinuria, Hypocalcemia.

Can Regorafenib be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. Can cause fetal harm: no human data, but it caused total pregnancy loss and malformations (heart, kidney, skeleton, cleft palate) in rats and rabbits at below human exposure. Avoid; use effective contraception during and for 2 months after treatment (men too). Breastfeeding: Unsafe. No human milk data; it passes into rat milk. Over 99% protein bound, but a metabolite with a half-life of up to 70 hours could build up in the infant. Do not breastfeed during treatment and for 2 weeks after the last dose.

What does Regorafenib interact with?

MediHelp lists 118 known interactions for Regorafenib. Major: 41 · Moderate: 60 · Minor: 17. The most serious include Apalutamide, Atazanavir, Carbamazepine.

在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查

在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。

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