藥物交互作用
Dasatinib + Sodium bicarbonate
嚴重程度: 中度
Dasatinib and Sodium bicarbonate: moderate interaction.
最後更新
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摘要
Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
用白話說明這項交互作用的意義
Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sodium bicarbonate belongs to Gastrointestinal Tract.
為什麼會發生
Raised gastric pH reduces dissolution and absorption of dasatinib, which is a pH-dependent weak base.
處置方式
If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dasatinib 的其他交互作用
Sodium bicarbonate 的其他交互作用
常見問題
Can I take Dasatinib with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
How serious is the interaction between Dasatinib and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
