藥物交互作用
Daunorubicin + Ponatinib
嚴重程度: 嚴重
Daunorubicin and Ponatinib: major interaction.
最後更新
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摘要
Ponatinib inhibits P-gp and BCRP and may increase daunorubicin exposure. Both agents carry cardiac toxicity and myelosuppression, so combined effects may be significant.
用白話說明這項交互作用的意義
Daunorubicin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Ponatinib belongs to Oncology.
為什麼會發生
Ponatinib inhibits P-gp and BCRP efflux, with additive cardiovascular and hematologic toxicity.
處置方式
Monitor cardiac function (including LVEF) and blood counts closely; reduce daunorubicin dose if toxicity appears.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Daunorubicin 的其他交互作用
Ponatinib 的其他交互作用
常見問題
Can I take Daunorubicin with Ponatinib?
MediHelp rates the interaction as major. Daunorubicin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponatinib inhibits P-gp and BCRP and may increase daunorubicin exposure. Both agents carry cardiac toxicity and myelosuppression, so combined effects may be significant.
How serious is the interaction between Daunorubicin and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function (including LVEF) and blood counts closely; reduce daunorubicin dose if toxicity appears.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
