藥物交互作用
Clarithromycin + Ponatinib
嚴重程度: 嚴重
Clarithromycin and Ponatinib: major interaction.
最後更新
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摘要
Clarithromycin may markedly increase ponatinib concentrations, raising the risk of arterial occlusion, heart failure, hepatotoxicity and pancreatitis.
用白話說明這項交互作用的意義
Clarithromycin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Ponatinib belongs to Oncology.
為什麼會發生
Clarithromycin is a strong CYP3A4 inhibitor that reduces the metabolism of ponatinib.
處置方式
Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, reduce the ponatinib dose as per labeling and monitor for cardiovascular and hepatic toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Ponatinib 的其他交互作用
常見問題
Can I take Clarithromycin with Ponatinib?
MediHelp rates the interaction as major. Clarithromycin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may markedly increase ponatinib concentrations, raising the risk of arterial occlusion, heart failure, hepatotoxicity and pancreatitis.
How serious is the interaction between Clarithromycin and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, reduce the ponatinib dose as per labeling and monitor for cardiovascular and hepatic toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
