藥物交互作用
Deferasirox + Repaglinide
嚴重程度: 嚴重
Deferasirox and Repaglinide: major interaction.
最後更新
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摘要
Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.
用白話說明這項交互作用的意義
Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Repaglinide belongs to Endocrine.
為什麼會發生
Deferasirox inhibits CYP2C8, a key pathway for repaglinide clearance.
處置方式
Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Repaglinide 的其他交互作用
Deferasirox 的其他交互作用
常見問題
Can I take Deferasirox with Repaglinide?
MediHelp rates the interaction as major. Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.
How serious is the interaction between Deferasirox and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
