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藥物交互作用

Gemfibrozil + Repaglinide

嚴重程度: 禁忌併用

Gemfibrozil and Repaglinide: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result.

用白話說明這項交互作用的意義

Gemfibrozil and Repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Gemfibrozil belongs to Cardiovascular; Repaglinide belongs to Endocrine.

證據等級: High

為什麼會發生

CYP2C8/OATP1B1 inhibition markedly increases repaglinide exposure

處置方式

Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Gemfibrozil 與 Repaglinide 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Gemfibrozil with Repaglinide?

MediHelp rates the interaction as contraindicated. Gemfibrozil and Repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result.

How serious is the interaction between Gemfibrozil and Repaglinide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.

What other medicines interact with Gemfibrozil?

MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.

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