藥物交互作用
Deferiprone + Mitoxantrone
嚴重程度: 嚴重
Deferiprone and Mitoxantrone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can cause neutropenia, and deferiprone can cause agranulocytosis. Together they increase the risk of severe neutropenia and serious infection.
用白話說明這項交互作用的意義
Deferiprone and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
為什麼會發生
Additive bone marrow suppression.
處置方式
Avoid if an alternative exists; otherwise monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mitoxantrone 的其他交互作用
Deferiprone 的其他交互作用
常見問題
Can I take Deferiprone with Mitoxantrone?
MediHelp rates the interaction as major. Deferiprone and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause neutropenia, and deferiprone can cause agranulocytosis. Together they increase the risk of severe neutropenia and serious infection.
How serious is the interaction between Deferiprone and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; otherwise monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
