藥物交互作用
Delamanid + Ritonavir
嚴重程度: 嚴重
Delamanid and Ritonavir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.
用白話說明這項交互作用的意義
Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Delamanid belongs to Anti Bacterial; Ritonavir belongs to Anti Virals.
為什麼會發生
CYP3A4 inhibition by ritonavir reduces clearance of the delamanid metabolite DM-6705, increasing QT-prolonging exposure.
處置方式
Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Delamanid 的其他交互作用
Ritonavir 的其他交互作用
常見問題
Can I take Delamanid with Ritonavir?
MediHelp rates the interaction as major. Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.
How serious is the interaction between Delamanid and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Rifampicin, Moxifloxacin. The full list is on the Delamanid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
