藥物交互作用

Amiodarone + Ritonavir

嚴重程度: 禁忌併用

Amiodarone and Ritonavir: contraindicated interaction.

最後更新 13 十月 2026

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本頁的臨床內容僅提供英文版。

摘要

Ritonavir strongly inhibits CYP3A4 and may raise amiodarone levels, risking bradycardia, QT prolongation and torsades de pointes. Ritonavir labeling lists this combination as contraindicated.

用白話說明這項交互作用的意義

Amiodarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.

證據等級: Moderate

為什麼會發生

Ritonavir inhibits CYP3A4 metabolism of amiodarone.

處置方式

Avoid the combination; choose an alternative antiarrhythmic or antiretroviral.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Amiodarone 與 Ritonavir 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Amiodarone with Ritonavir?

MediHelp rates the interaction as contraindicated. Amiodarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and may raise amiodarone levels, risking bradycardia, QT prolongation and torsades de pointes. Ritonavir labeling lists this combination as contraindicated.

How serious is the interaction between Amiodarone and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative antiarrhythmic or antiretroviral.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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摘要