藥物交互作用
Diflunisal + Pralatrexate
嚴重程度: 嚴重
Diflunisal and Pralatrexate: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
用白話說明這項交互作用的意義
Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
為什麼會發生
Competition for renal tubular secretion and NSAID-related reduction in renal blood flow decrease pralatrexate clearance.
處置方式
Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Diflunisal 的其他交互作用
Pralatrexate 的其他交互作用
常見問題
Can I take Diflunisal with Pralatrexate?
MediHelp rates the interaction as major. Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
How serious is the interaction between Diflunisal and Pralatrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
