藥物交互作用
Dihydroergotamine intranasal + Dobutamine
嚴重程度: 嚴重
Dihydroergotamine intranasal and Dobutamine: major interaction.
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摘要
Intranasal dihydroergotamine is absorbed systemically and can cause vasoconstriction, which may add to dobutamine's cardiovascular stimulation. This may lead to hypertension and reduced peripheral perfusion. The evidence is mainly theoretical.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Dobutamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive pharmacodynamic vasoconstriction and cardiovascular stimulation.
處置方式
Avoid giving dihydroergotamine to patients on dobutamine infusion; use another migraine therapy. If unavoidable, monitor blood pressure and limb perfusion closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dobutamine 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Dobutamine?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Dobutamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal dihydroergotamine is absorbed systemically and can cause vasoconstriction, which may add to dobutamine's cardiovascular stimulation. This may lead to hypertension and reduced peripheral perfusion. The evidence is mainly theoretical.
How serious is the interaction between Dihydroergotamine intranasal and Dobutamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving dihydroergotamine to patients on dobutamine infusion; use another migraine therapy. If unavoidable, monitor blood pressure and limb perfusion closely.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine, Ergotamine. The full list is on the Dobutamine page.
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