藥物交互作用
Dobutamine + Ergotamine
嚴重程度: 嚴重
Dobutamine and Ergotamine: major interaction.
最後更新
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摘要
Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
用白話說明這項交互作用的意義
Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Ergotamine belongs to Central Nervous System.
為什麼會發生
Additive vasoconstriction (pharmacodynamic)
處置方式
Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dobutamine 的其他交互作用
Ergotamine 的其他交互作用
常見問題
Can I take Dobutamine with Ergotamine?
MediHelp rates the interaction as major. Dobutamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes potent peripheral and coronary vasoconstriction, and dobutamine stimulates adrenergic receptors, adding vasoconstrictor and pressor effects. The combination can produce severe hypertension and peripheral or cardiac ischaemia.
How serious is the interaction between Dobutamine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a vasoactive agent is needed in a patient exposed to ergotamine, use the lowest dose and monitor perfusion and blood pressure.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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