藥物交互作用
Dobutamine + Linezolid
嚴重程度: 嚴重
Dobutamine and Linezolid: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
用白話說明這項交互作用的意義
Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.
為什麼會發生
Reduced catecholamine degradation (MAO inhibition) with sympathomimetic stimulation
處置方式
Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Linezolid 的其他交互作用
Dobutamine 的其他交互作用
常見問題
Can I take Dobutamine with Linezolid?
MediHelp rates the interaction as major. Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
How serious is the interaction between Dobutamine and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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