藥物交互作用
Dihydroergotamine intranasal + Posaconazole
嚴重程度: 禁忌併用
Dihydroergotamine intranasal and Posaconazole: contraindicated interaction.
最後更新
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摘要
Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Posaconazole strongly inhibits CYP3A4-mediated clearance of dihydroergotamine.
處置方式
Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Posaconazole 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
How serious is the interaction between Dihydroergotamine intranasal and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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