藥物交互作用
Dihydroergotamine + Posaconazole
嚴重程度: 禁忌併用
Dihydroergotamine and Posaconazole: contraindicated interaction.
最後更新
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摘要
Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
用白話說明這項交互作用的意義
Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
為什麼會發生
Posaconazole strongly inhibits CYP3A4, the main metabolic pathway of dihydroergotamine.
處置方式
Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Posaconazole 的其他交互作用
Dihydroergotamine 的其他交互作用
常見問題
Can I take Dihydroergotamine with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
How serious is the interaction between Dihydroergotamine and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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