Drug interactions
Dihydroergotamine intranasal + Posaconazole
Severity: Contraindicated
Dihydroergotamine intranasal and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
What this interaction means in plain words
Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Posaconazole strongly inhibits CYP3A4-mediated clearance of dihydroergotamine.
What to do
Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
- Dronedarone + Posaconazole Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole can substantially increase systemic dihydroergotamine levels after intranasal dosing. This raises the risk of serious vasospastic ischemia of the extremities and central nervous system.
How serious is the interaction between Dihydroergotamine intranasal and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; it is contraindicated in labeling. Choose a non-ergot acute migraine therapy during posaconazole treatment.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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