藥物交互作用
Dihydroergotamine intranasal + Voriconazole
嚴重程度: 禁忌併用
Dihydroergotamine intranasal and Voriconazole: contraindicated interaction.
最後更新
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摘要
Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
用白話說明這項交互作用的意義
Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Strong CYP3A4 inhibition by voriconazole reduces dihydroergotamine clearance.
處置方式
Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Voriconazole 的其他交互作用
常見問題
Can I take Dihydroergotamine intranasal with Voriconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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