藥物交互作用
Carbamazepine + Voriconazole
嚴重程度: 禁忌併用
Carbamazepine and Voriconazole: contraindicated interaction.
最後更新 來源: US FDA label
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摘要
Carbamazepine markedly lowers voriconazole concentrations, risking antifungal treatment failure. Voriconazole may in turn raise carbamazepine levels, causing toxicity. Voriconazole labeling contraindicates its use with carbamazepine.
用白話說明這項交互作用的意義
Carbamazepine and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
為什麼會發生
Carbamazepine induces CYP3A4 and other CYP enzymes, accelerating voriconazole metabolism, while voriconazole inhibits CYP3A4 and may reduce carbamazepine clearance.
處置方式
Do not combine. Use an alternative antifungal that is not affected, or an alternative anticonvulsant with no enzyme-inducing effect, according to the infection and seizure type.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
- Vfend (voriconazole) Prescribing Information - Contraindications and Drug Interactions — FDA Label
- Voriconazole Summary of Product Characteristics — EMA SmPC
Carbamazepine 的其他交互作用
Voriconazole 的其他交互作用
常見問題
Can I take Carbamazepine with Voriconazole?
MediHelp rates the interaction as contraindicated. Carbamazepine and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly lowers voriconazole concentrations, risking antifungal treatment failure. Voriconazole may in turn raise carbamazepine levels, causing toxicity. Voriconazole labeling contraindicates its use with carbamazepine.
How serious is the interaction between Carbamazepine and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative antifungal that is not affected, or an alternative anticonvulsant with no enzyme-inducing effect, according to the infection and seizure type.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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