藥物交互作用
Dopamine + Selegiline transdermal
嚴重程度: 禁忌併用
Dopamine and Selegiline transdermal: contraindicated interaction.
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摘要
Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.
用白話說明這項交互作用的意義
Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition reduces dopamine breakdown and increases norepinephrine stores, amplifying sympathomimetic effects.
處置方式
Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dopamine 的其他交互作用
常見問題
Can I take Dopamine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.
How serious is the interaction between Dopamine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Amitriptyline. The full list is on the Dopamine page.
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