藥物交互作用
Dronedarone + Idelalisib
嚴重程度: 禁忌併用
Dronedarone and Idelalisib: contraindicated interaction.
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摘要
Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
用白話說明這項交互作用的意義
Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Idelalisib belongs to Oncology.
為什麼會發生
Strong CYP3A inhibition by idelalisib reduces dronedarone clearance.
處置方式
Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dronedarone 的其他交互作用
Idelalisib 的其他交互作用
常見問題
Can I take Dronedarone with Idelalisib?
MediHelp rates the interaction as contraindicated. Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
How serious is the interaction between Dronedarone and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
